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Dominant tolerance and linked suppression induced by therapeutic antibodies do not depend on Fas-FasL interactions.

Abstract:

BACKGROUND: Nonlytic anti-CD4 monoclonal antibody therapy can be used to induce transplantation tolerance in rodent models. Such tolerance is often associated with dominant regulation, mediated by CD4+ cells, and characterized by infectious tolerance and linked suppression. Understanding the mechanisms by which CD4+ regulatory cells function may improve the manner in which current immunosuppressants are applied and may lead to the development of new tolerance-inducing therapeutics. Fas-mediat...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Transplantation
Volume:
69
Issue:
8
Pages:
1683-1689
Publication date:
2000-04-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Source identifiers:
14231

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