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Pyridostigmine partially reverses dexamethasone-induced inhibition of the growth hormone response to growth hormone-releasing hormone.

Abstract:

The GH response to insulin-induced hypoglycaemia and growth hormone-releasing hormone (GHRH) has been shown to be impaired in subjects with Cushing's syndrome and in healthy volunteers given oral glucocorticoids. Pyridostigmine is an anticholinesterase that stimulates GH secretion, probably by inhibition of hypothalamic somatostatin secretion. This work was designed to study the site of action of glucocorticoids in inhibiting the secretion of GH. Eight healthy male volunteers were studied on ...

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Publication status:
Published

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Publisher copy:
10.1677/joe.0.1340513

Authors


Trainer, PJ More by this author
Savage, MO More by this author
Grossman, AB More by this author
Besser, GM More by this author
Journal:
The Journal of endocrinology
Volume:
134
Issue:
3
Pages:
513-517
Publication date:
1992-09-05
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
URN:
uuid:c6df481c-b377-4170-9af0-7c6e8c419a5f
Source identifiers:
138161
Local pid:
pubs:138161

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