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Journal article

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

Abstract:

VEGF and Angiopoietin-1 requisitely collaborate during blood vessel development. While Angiopoietin-1 obligately activates its Tie2 receptor, Angiopoietin-2 can activate Tie2 on some cells, while it blocks Tie2 activation on others. Our analysis of mice lacking Angiopoietin-2 reveals that Angiopoietin-2 is dispensable for embryonic vascular development but is requisite for subsequent angiogenic remodeling. Unexpectedly, mice lacking Angiopoietin-2 also exhibit major lymphatic vessel defects. ...

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Publication status:
Published

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Journal:
Developmental cell
Volume:
3
Issue:
3
Pages:
411-423
Publication date:
2002-09-05
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
URN:
uuid:c6d76432-2180-422a-97af-d6c845e97048
Source identifiers:
102444
Local pid:
pubs:102444

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