Journal article
Angiocrine signals regulate quiescence and therapy resistance in bone metastasis
- Abstract:
-
Bone provides supportive microenvironments for hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) and is a frequent site of metastasis. While incidences of bone metastases increase with age, the properties of the bone marrow microenvironment that regulate dormancy and reactivation of disseminated tumor cells (DTCs) remain poorly understood. Here, we elucidate the age-associated changes in the bone secretome that trigger proliferation of HSCs, MSCs, and DTCs in the aging bone ma...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation
- Journal:
- JCI Insight Journal website
- Volume:
- 4
- Issue:
- 13
- Article number:
- e125679
- Publication date:
- 2019-07-11
- Acceptance date:
- 2019-05-25
- DOI:
- EISSN:
-
2379-3708
Item Description
- Language:
- English
- Pubs id:
-
pubs:1031385
- UUID:
-
uuid:c6cfe23a-b25b-41d2-a608-726ee3dcb50a
- Local pid:
- pubs:1031385
- Source identifiers:
-
1031385
- Deposit date:
- 2019-07-12
Terms of use
- Copyright holder:
- Singh et al
- Copyright date:
- 2019
- Notes:
- © 2019 Singh et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License
- Licence:
- CC Attribution (CC BY)
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