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Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405 peptide bond.

Abstract:

Matrix metalloproteinases (MMPs) can degrade a number of proteins that constitute the extracellular matrix. Previous studies have shown that atherosclerotic plaques contain substantial amounts of fibrin(ogen)-related antigen, and more recently, MMPs have been identified in such lesions. The hypothesis that MMPs play a role in the degradation of fibrinogen (Fg) and cross-linked fibrin (XL-Fb) was investigated. Fibrinogen became thrombin-unclottable when treated with matrix metalloproteinase 3 ...

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Publisher copy:
10.1021/bi960730c

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Kudryk, BJ More by this author
Journal:
Biochemistry
Volume:
35
Issue:
40
Pages:
13056-13063
Publication date:
1996-10-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:c6c9cae3-3653-48a6-b87e-ebb3f1b739b3
Source identifiers:
411400
Local pid:
pubs:411400

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