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P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions.

Abstract:

The ookinete surface proteins (P25 and P28) are proven antimalarial transmission-blocking vaccine targets, yet their biological functions are unknown. By using single (Sko) and double gene knock-out (Dko) Plasmodium berghei parasites, we show that P25 and P28 share multiple functions during ookinete/oocyst development. In the midgut of mosquitoes, the formation of ookinetes lacking both proteins (Dko parasites) is significantly inhibited due to decreased protection against lethal factors, inc...

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Publisher copy:
10.1093/emboj/20.15.3975

Authors


Dimopoulos, G More by this author
van Lin, LH More by this author
de Koning-Ward, TF More by this author
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Journal:
The EMBO journal
Volume:
20
Issue:
15
Pages:
3975-3983
Publication date:
2001-08-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:c6c279e5-a6e4-4bf8-b579-5c34f9c2127c
Source identifiers:
255607
Local pid:
pubs:255607

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