Journal article

P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions.

Abstract:: The ookinete surface proteins (P25 and P28) are proven antimalarial transmission-blocking vaccine targets, yet their biological functions are unknown. By using single (Sko) and double gene knock-out (Dko) Plasmodium berghei parasites, we show that P25 and P28 share multiple functions during ookinete/oocyst development. In the midgut of mosquitoes, the formation of ookinetes lacking both proteins (Dko parasites) is significantly inhibited due to decreased protection against lethal factors, inc...
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APA Style

Tomas, A., Margos, G., Dimopoulos, G., van Lin, L., de Koning-Ward, T., Sinha, R., Lupetti, P., Beetsma, A., Rodriguez, M., Karras, M., Hager, A., Mendoza, J., Butcher, G., Kafatos, F., Janse, C., Waters, A., & Sinden, R. (2001). P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions. EMBO Journal, 20(15), 3975–3983.

MLA Style

Tomas, A., et al. “P25 And P28 Proteins of the Malaria Ookinete Surface Have Multiple and Partially Redundant Functions.” EMBO Journal, vol. 20, no. 15, 2001, pp. 3975–83.

Chicago Style

Tomas, A, G Margos, G Dimopoulos, L van Lin, T de Koning-Ward, R Sinha, P Lupetti, et al. 2001. “P25 And P28 Proteins of the Malaria Ookinete Surface Have Multiple and Partially Redundant Functions.” EMBO Journal 20 (15): 3975–83.
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Publisher copy:: 10.1093/emboj/20.15.3975

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+ Tomas, A More by this author

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+ Margos, G More by this author

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+ Dimopoulos, G More by this author

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+ van Lin, L More by this author

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+ de Koning-Ward, T More by this author

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Bibliographic Details

Journal:: EMBO journal More from this journal
Volume:: 20
Issue:: 15
Pages:: 3975-3983
Publication date:: 2001-08-01
DOI:: 10.1093/emboj/20.15.3975
EISSN:: 1460-2075
ISSN:: 0261-4189

Item Description

Language:: English
Keywords:: Epithelium

Antigens, Surface

Plasmodium berghei

Antigens, Protozoan

Protozoan Proteins

Animals

Digestive System

Anopheles
Pubs id:: pubs:255607
UUID:: uuid:c6c279e5-a6e4-4bf8-b579-5c34f9c2127c
Local pid:: pubs:255607
Source identifiers:: 255607
Deposit date:: 2013-02-20

Terms of use

Copyright date:: 2001

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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