The ookinete surface proteins (P25 and P28) are proven antimalarial transmission-blocking vaccine targets, yet their biological functions are unknown. By using single (Sko) and double gene knock-out (Dko) Plasmodium berghei parasites, we show that P25 and P28 share multiple functions during ookinete/oocyst development. In the midgut of mosquitoes, the formation of ookinetes lacking both proteins (Dko parasites) is significantly inhibited due to decreased protection against lethal factors, inc...Expand abstract
- Publisher copy:
- Copyright date:
P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions.
If you are the owner of this record, you can report an update to it here: Report update to this record