Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand.

Journal article

A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime (n = 8), amoxicillin-clavulanic acid (n = 4), or both drugs (n = 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.

Authors: Wuthiekanun, V; Amornchai, P; Saiprom, N; Chantratita, N; Chierakul, W

• Publication status: Published
• Journal: Antimicrobial agents and chemotherapy
• Volume: 55
• Issue: 11
• Pages: 5388-5391
• Publication date: 2011-11-01
• DOI: 10.1128/aac.05517-11
• EISSN: 1098-6596
• ISSN: 0066-4804
• Language: English
• Keywords: Amoxicillin-Potassium Clavulanate Combination; Melioidosis; Anti-Bacterial Agents; Burkholderia pseudomallei; Ceftazidime; Thienamycins; Humans; Drug Resistance, Bacterial; Thailand; Imipenem