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How do monoclonal antibodies induce tolerance? A role for infectious tolerance?

Abstract:

One of the major goals in therapeutic immunosuppression has been to achieve long-term benefit from short-term therapy. The discovery in the mild-1980s that CD4 antibodies can induce immunological tolerance without depleting CD4+ T cells has reawakened interest in the use of nondepleting monoclonal antibodies for reprogramming the immune system in autoimmunity and in transplantation. Since that time, antibodies to CD11a, CD4OL, CD25, CD3, and CTLA4-Ig have all been shown capable of facilitatin...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Cobbold, S More by this author
Journal:
Annual review of immunology
Volume:
16
Issue:
1
Pages:
619-644
Publication date:
1998
DOI:
EISSN:
1545-3278
ISSN:
0732-0582
URN:
uuid:c66c4a3a-3207-4eb3-85ad-f59d1735af92
Source identifiers:
26081
Local pid:
pubs:26081

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