Journal article icon

Journal article

Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility.

Abstract:

Killer immunoglobulin-like receptors (KIRs) are expressed on natural killer cells and some T-cell subsets and produce either activation or inhibitory signals upon binding with the appropriate human leucocyte antigen (HLA) ligand on target cells. Recent genetic association studies have implicated KIR genotype in the development of several inflammatory conditions. Ulcerative colitis (UC) is an inflammatory disorder of the colonic mucosa that results from an inappropriate activation of the immun...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.gene.6364333

Authors


Cummings, JR More by this author
Jewell, DP More by this author
Expand authors...
Journal:
Genes and immunity
Volume:
7
Issue:
7
Pages:
576-582
Publication date:
2006-10-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:c6533f3f-c06b-4190-a09c-ab75873dbb5c
Source identifiers:
135767
Local pid:
pubs:135767

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP