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Journal article

Cryo-electron tomographic structure of an immunodeficiency virus envelope complex in situ.

Abstract:

The envelope glycoprotein (Env) complexes of the human and simian immunodeficiency viruses (HIV and SIV, respectively) mediate viral entry and are a target for neutralizing antibodies. The receptor binding surfaces of Env are in large part sterically occluded or conformationally masked prior to receptor binding. Knowledge of the unliganded, trimeric Env structure is key for an understanding of viral entry and immune escape, and for the design of vaccines to elicit neutralizing antibodies. We ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.0020083

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Fuller, SD
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
2
Issue:
8
Pages:
e83
Publication date:
2006-08-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:c646df6e-68dc-4bd3-8796-6426f9d8c369
Source identifiers:
94774
Local pid:
pubs:94774

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