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Social evolution in micro-organisms and a Trojan horse approach to medical intervention strategies

Abstract:

Medical science is typically pitted against the evolutionary forces acting upon infective populations of bacteria. As an alternative strategy, we could exploit our growing understanding of population dynamics of social traits in bacteria to help treat bacterial disease. In particular, population dynamics of social traits could be exploited to introduce less virulent strains of bacteria, or medically beneficial alleles into infective populations. We discuss how bacterial strains adopting diffe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rstb.2009.0055

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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
More by this author
Institution:
University of Nottingham
Department:
School of Molecular Medical Sciences,Centre for Biomolecular Sciences
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Leverhulme Trust More from this funder
Wellcome Trust More from this funder
Publisher:
Royal Society Publisher's website
Journal:
Philosophical Transactions of the Royal Society B Journal website
Volume:
364
Issue:
1533
Pages:
3157-3168
Publication date:
2009-11-05
DOI:
EISSN:
1471-2970
URN:
uuid:c6448409-1631-44ec-b736-7b70ef7ce649
Local pid:
ora:3167
Language:
English
Keywords:
Subjects:

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