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Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Abstract:

Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inflammation. Here we performed 16S sequencing on 114 stool samples from rheumatoid arthritis patients and controls, and shotgun sequencing on a subset of 44 such samples. We identified the presence of Prevotella copri as strongly correlated with dis...

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Publisher copy:
10.7554/eLife.01202.001

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Journal:
eLife
Volume:
2013
Issue:
2
Publication date:
2013-11-05
DOI:
EISSN:
2050-084X
URN:
uuid:c63a0a59-1008-435d-8fdf-e5a23aeee579
Source identifiers:
440731
Local pid:
pubs:440731

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