Molecular epidemiology of DNA repair genes in bladder cancer.

Journal article

Bladder cancer is a common disease, whose major risk factors include smoking and occupational exposure to chemicals. Superficial bladder cancer has significant healthcare cost implications due to the need for repeated cystoscopic surveillance. Chemical carcinogens can undergo metabolic activation and detoxification in the liver and polymorphisms in the relevant genes have been shown to be associated with bladder cancer risk. In addition, DNA repair enzymes are required to repair the DNA damag...

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Authors: Kiltie, A

• Journal: Methods in molecular biology (Clifton, N.J.)
• Volume: 472
• Pages: 281-306
• Publication date: 2009-01-01
• DOI: 10.1007/978-1-60327-492-0_12
• EISSN: 1940-6029
• ISSN: 1064-3745
• Language: English
• Keywords: Humans; DNA Repair; Molecular Epidemiology; Case-Control Studies; Genome-Wide Association Study; Urinary Bladder Neoplasms; Carcinogens