Journal article icon

Journal article

Isolation of the human chromosomal band Xq28 within somatic cell hybrids by fragile X site breakage.

Abstract:

The chromosomal fragile-site mapping to Xq27.3 is associated with a frequent form of mental retardation and is prone to breakage after induced deoxyribonucleotide pool perturbation. The human hypoxanthine phosphoribosyltransferase (HPRT) and glucose-6-phosphate dehydrogenase (G6PD) genes flank the fragile X chromosome site and can be used to monitor integrity of the site in human-hamster somatic cell hybrids deficient in the rodent forms of these activities. After induction of the fragile X s...

Expand abstract

Actions


Access Document


Publisher copy:
10.1073/pnas.87.10.3856

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
87
Issue:
10
Pages:
3856-3860
Publication date:
1990-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c632d289-187c-48bd-9fd1-a8b72e35c985
Source identifiers:
310302
Local pid:
pubs:310302

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP