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Isolation of the human chromosomal band Xq28 within somatic cell hybrids by fragile X site breakage.

Abstract:

The chromosomal fragile-site mapping to Xq27.3 is associated with a frequent form of mental retardation and is prone to breakage after induced deoxyribonucleotide pool perturbation. The human hypoxanthine phosphoribosyltransferase (HPRT) and glucose-6-phosphate dehydrogenase (G6PD) genes flank the fragile X chromosome site and can be used to monitor integrity of the site in human-hamster somatic cell hybrids deficient in the rodent forms of these activities. After induction of the fragile X s...

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Publisher copy:
10.1073/pnas.87.10.3856

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
87
Issue:
10
Pages:
3856-3860
Publication date:
1990-05-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
310302

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