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Journal article

Selection of diagnostic cutoffs for murine typhus IgM and IgG immunofluorescence assay: a systematic review

Abstract:

Murine typhus is a neglected but widespread infectious disease that results in acute fever. The immunofluorescence assay (IFA) is the “gold standard” to identify IgM or IgG antibodies, although there is a lack of standardization in methodologies. The objective of this review is to summarize 1) the differences in published methodologies, 2) the diagnostic cutoff titers, and 3) the justification of diagnostic cutoffs. Searches were performed by combining the following search terms: “murine typh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4269/ajtmh.19-0818

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-1187-2712
More from this funder
Grant:
106698/Z/14/A milestone
106698/B/14/Z milestone
Publisher:
American Society of Tropical Medicine and Hygiene Publisher's website
Journal:
American Journal of Tropical Medicine and Hygiene Journal website
Volume:
103
Issue:
1
Pages:
55-63
Publication date:
2020-04-06
Acceptance date:
2020-02-18
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
Pmid:
32274984
Language:
English
Keywords:
Pubs id:
1099467
Local pid:
pubs:1099467
Deposit date:
2020-06-01

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