The effect of amiloride on the airway response to metabisulphite in asthma: a negative report.

Journal article

Frusemide, a loop diuretic, has been shown to potently inhibit several indirect bronchoconstrictor challenges in asthma. The mechanism by which nebulized frusemide protects against indirect bronchoconstrictor stimuli in asthma is not known. One mechanism could be related to inhibition of sodium transport. If this is the case, then amiloride, another inhibitor of sodium transport, should also protect against indirect bronchoconstrictor challenges. Ten subjects with mild asthma were administere...

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Authors: Baldwin, DR; Grange, K; Pavord, I; Knox, A

• Journal: European respiratory journal
• Volume: 5
• Issue: 10
• Pages: 1189-1192
• Publication date: 1992-11-01
• EISSN: 1399-3003
• ISSN: 0903-1936
• Language: English
• Keywords: Administration, Inhalation; Furosemide; Bronchial Provocation Tests; Ion Transport; Double-Blind Method; Forced Expiratory Volume; Sulfites; Adult; Middle Aged; Asthma; Male; Bronchoconstriction; Amiloride; Humans