Journal article
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
- Abstract:
-
Small molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents. N(epsilon)-Methylation of lysine residues on histone tails is one of a number of post-translational modifications that together enable transcriptional regulation. Histone lysine demethylases antagonize the action of histone methyltransferases in a site- and methylation state-specific manner. N(epsilon)-Methyllysine dem...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Structural Genomics Consortium
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Biotechnology and Biological Research Council
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Wellcome Trust
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National Institutes of Health
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Commonwealth Scholarship Commission in the United Kingdom
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 5
- Issue:
- 11
- Article number:
- e15535
- Publication date:
- 2010-01-01
- DOI:
- EISSN:
-
1932-6203
- ISSN:
-
1932-6203
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:c6104d70-028f-46bd-b02d-223982e7f869
- Local pid:
- pubs:99853
- Source identifiers:
-
99853
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- King et al
- Copyright date:
- 2010
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
- Licence:
- CC Attribution (CC BY)
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