Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort

Rothwell, J; Murphy, N; Bešević, J; Schmidt, J

Journal article

Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort

Abstract:: Background & Aims:
Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer cohort.

Methods:
Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.

Results:
Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.

Conclusions:
Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Rothwell, J., Murphy, N., Bešević, J., & Schmidt, J. (2020). Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort. Clinical Gastroenterology and Hepatology, 20(5), e1061–e1082.

MLA Style

Rothwell, J, et al. “Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risks in a European Cohort.” Clinical Gastroenterology and Hepatology, vol. 20, no. 5, 2020, pp. e1061–e1082.

Chicago Style

Rothwell, J, N Murphy, J Bešević, and J Schmidt. 2020. “Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risks in a European Cohort.” Clinical Gastroenterology and Hepatology 20 (5): e1061–e1082.
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