The influence of antigen organization on B cell responsiveness.

Journal article

The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen pr...

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Authors: Bachmann, M; Rohrer, U; Kündig, T; Bürki, K; Hengartner, H

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 262
• Issue: 5138
• Pages: 1448-1451
• Publication date: 1993-11-01
• DOI: 10.1126/science.8248784
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Membrane Glycoproteins; Antibody Affinity; Vesicular stomatitis Indiana virus; Neutralization Tests; T-Lymphocytes, Helper-Inducer; B-Lymphocytes; Mice; Mice, Transgenic; Lymphocyte Activation; Viral Envelope Proteins; Immunoglobulin M; Immunoglobulin G; Animals; Immunization; Antibodies, Viral; Macrophages, Peritoneal; Immune Tolerance