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Development of models of active ion transport for whole−cell modelling: cardiac sodium−potassium pump as a case study

Abstract:

This study presents a method for the reduction of biophysically-based kinetic models for the active transport of ions. A lumping scheme is presented which exploits the differences in timescales associated with fast and slow transitions between model states, while maintaining the thermodynamic properties of the model. The goal of this approach is to contribute to modelling of the effects of disturbances to metabolism, associated with ischaemic heart disease, on cardiac cell function. The appro...

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Authors


N.P. Smith More by this author
E.J. Crampin More by this author
Journal:
Prog Biophys Mol Biol
Volume:
85
Issue:
2−3
Pages:
387-405
Publication date:
2004
URN:
uuid:c5f8e59f-ae9d-40b4-8339-3547e6bafcc3
Local pid:
cs:1512

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