Journal article
Physiological responses to retinopathy of prematurity screening: indirect ophthalmoscopy versus ultra-widefield retinal imaging
- Abstract:
-
Background/Aims
Retinopathy of prematurity (ROP) screening is vital for early disease detection in very premature infants but can cause physiological instability. This study compares the physiological response to binocular indirect ophthalmoscopy (BIO) with indentation and non-contact ultra-widefield (UWF) retinal imaging in non-ventilated neonates. The impact of the Dandle WRAP, a specialised swaddling aid, on UWF imaging was also assessed.
Methods
This retrospective study included 86 ROP screening events in 66 non-ventilated infants aged 35.3 weeks (range 30.6–44.6). Vital signs were continuously recorded, evaluating immediate (within 15 min) and longer-term (within 12 h) physiological responses.
Results
ROP screening significantly increased heart and respiratory rates and decreased oxygen saturation within 15 min of screening. No significant differences in physiological responses were found between BIO and UWF imaging, although there was a trend towards lower maximum heart rate with UWF imaging. The Dandle WRAP did not significantly alter physiological responses but improved the ease and speed of UWF imaging.
Conclusion
UWF imaging does not increase physiological instability compared to BIO in non-ventilated infants. Specialised swaddling aids may facilitate the imaging procedure.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.9MB, Terms of use)
-
- Publisher copy:
- 10.1038/s41390-025-03906-4
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Funding agency for:
- Xue, K
- Hartley, C
- Grant:
- 216593/Z/19/Z
- 213486/Z/18/Z
+ Commonwealth Scholarship Commission
More from this funder
- Funder identifier:
- https://ror.org/051x4wh35
- Funding agency for:
- Usman, F
+ NIHR Oxford Musculoskeletal Biomedical Research Centre
More from this funder
- Funder identifier:
- https://ror.org/00aps1a34
- Funding agency for:
- Xue, K
- Publisher:
- Springer Nature
- Journal:
- Pediatric Research More from this journal
- Volume:
- 98
- Issue:
- 5
- Pages:
- 1801–1808
- Place of publication:
- United States
- Publication date:
- 2025-02-13
- Acceptance date:
- 2024-12-30
- DOI:
- EISSN:
-
1530-0447
- ISSN:
-
0031-3998
- Pmid:
-
39948384
- Language:
-
English
- Pubs id:
-
2085961
- Local pid:
-
pubs:2085961
- Deposit date:
-
2025-02-19
- ARK identifier:
Terms of use
- Copyright holder:
- Purohit et al.
- Copyright date:
- 2025
- Rights statement:
- © The Author(s) 2025. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record