Subventricular zone cytoarchitecture changes in autism.

Journal article

Autism is thought to be a neurodevelopmental disorder with symptoms developing during neonatal neurogenesis in the subventricular zone (SVZ). Autism associated genes alter SVZ proliferation and cytoarchitecture, yet the response of the human SVZ in autism is unknown. Epilepsy drives neurogenesis in rodents, but it is unclear how epilepsy interacts with autism in SVZ responses. The striatal and septal SVZ derive from separate lineages in rodents and generate different interneuron types. Yet it...

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Authors: Kotagiri, P; Chance, SA; Szele, F; Esiri, M

• Publication status: Published
• Journal: Developmental neurobiology
• Volume: 74
• Issue: 1
• Pages: 25-41
• Publication date: 2014-01-01
• DOI: 10.1002/dneu.22127
• EISSN: 1932-846X
• ISSN: 1932-8451
• Language: English
• Keywords: Brain; Immunohistochemistry; Neurogenesis; Autistic Disorder; Female; Cohort Studies; Adult; Middle Aged; Lateral Ventricles; Cerebral Ventricles; Corpus Striatum; Neural Pathways; Child; Phenotype; Young Adult; Cell Movement; Aged; Humans; Adolescent; Autopsy; Neurons