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Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients.

Abstract:

BACKGROUND: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible. We studied the population pharmacokinetics of intra-rectal artesunate and the relationship with parasitological responses in patients with moderately severe falciparum malaria. METHODS AND FINDINGS: Adults and children in Africa and Southeast Asia with moderately severe malaria were rec...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.0030444

Authors


Simpson, JA More by this author
Agbenyega, T More by this author
Barnes, KI More by this author
Di Perri, G More by this author
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Funding agency for:
Nosten, F
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Funding agency for:
White, NJ
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
3
Issue:
11
Pages:
e444
Publication date:
2006-11-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:c5a65407-019d-4ffa-9e96-14bf91f250b1
Source identifiers:
13961
Local pid:
pubs:13961

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