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Local termination of 3'-5'-cyclic adenosine monophosphate signals: the role of A kinase anchoring protein-tethered phosphodiesterases.

Abstract:

A kinase anchoring proteins (AKAPs) belong to a family of functionally related proteins capable of binding protein kinase A (PKA) and tether it to relevant targets. In this way, AKAPs organize macromolecular complexes to segregate PKA activity and retain signal specificity. In the heart, AKAP-PKA interaction is central to the regulation of cardiac contractility. Phosphodiesterases belong to a large superfamily of enzymes that degrade 3'-5'-cyclic adenosine monophosphate (cAMP). They possess d...

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Authors


Stangherlin, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
Journal of cardiovascular pharmacology
Volume:
58
Issue:
4
Pages:
345-353
Publication date:
2011-10-05
DOI:
EISSN:
1533-4023
ISSN:
0160-2446
URN:
uuid:c5999b05-7da5-4162-ab4a-f57ae62e3c11
Source identifiers:
237553
Local pid:
pubs:237553

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