Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging.

Journal article

Bone diseases such as rickets and osteoporosis cause significant reduction in bone quantity and quality, which leads to mechanical abnormalities. However, the precise ultrastructural mechanism by which altered bone quality affects mechanical properties is not clearly understood. Here we demonstrate the functional link between altered bone quality (reduced mineralization) and abnormal fibrillar-level mechanics using a novel, real-time synchrotron X-ray nanomechanical imaging method to study a ...

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Authors: Karunaratne, A; Esapa, C; Hiller, J; Boyde, A; Head, R

• Publication status: Published
• Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
• Volume: 27
• Issue: 4
• Pages: 876-890
• Publication date: 2012-04-01
• DOI: 10.1002/jbmr.1495
• EISSN: 1523-4681
• ISSN: 0884-0431
• Language: English
• Keywords: X-Rays; Male; Electrons; Molecular Sequence Data; Female; Nanostructures; Mice, Inbred C57BL; Synchrotrons; Tensile Strength; PHEX Phosphate Regulating Neutral Endopeptidase; Stress, Mechanical; Biomechanical Phenomena; Scattering, Small Angle; Mice; Ethylnitrosourea; Calcification, Physiologic; Mutation, Missense; Familial Hypophosphatemic Rickets; Genotype; Genetic Diseases, X-Linked; Bone and Bones; Phenotype; Amino Acid Sequence; Animals