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Journal article

Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging.

Abstract:

Bone diseases such as rickets and osteoporosis cause significant reduction in bone quantity and quality, which leads to mechanical abnormalities. However, the precise ultrastructural mechanism by which altered bone quality affects mechanical properties is not clearly understood. Here we demonstrate the functional link between altered bone quality (reduced mineralization) and abnormal fibrillar-level mechanics using a novel, real-time synchrotron X-ray nanomechanical imaging method to study a ...

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Publication status:
Published

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Publisher copy:
10.1002/jbmr.1495

Authors


Karunaratne, A More by this author
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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
27
Issue:
4
Pages:
876-890
Publication date:
2012-04-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:c579e4cd-92ff-4566-85b4-9c33d1486e0a
Source identifiers:
320271
Local pid:
pubs:320271

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