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Journal article

Competition between CTL narrows the immune response induced by prime-boost vaccination protocols.

Abstract:

Recombinant vaccines encoding strings of virus- or tumor-derived peptides and/or proteins are currently being designed for use against both cancer and infectious diseases. These vaccines aim to induce cytotoxic immune responses against several Ags simultaneously. We developed a novel tetramer-based technique, based on chimeric HLA A2/H-2K(b) H chains, to directly monitor the CTL response to such vaccines in HLA-A2 transgenic mice. We found that priming and boosting with the same polyepitope c...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.168.9.4391

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
168
Issue:
9
Pages:
4391-4398
Publication date:
2002-05-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:c5763a8c-bb8d-4455-8a75-d30a6ae8cedb
Source identifiers:
32094
Local pid:
pubs:32094

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