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Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake.

Abstract:

Glucocorticoids increase adipocyte proliferation and differentiation, a process underpinned by the local reactivation of inactive cortisone to active cortisol within adipocytes catalyzed by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The adrenal sex steroid precursor dehydroepiandrosterone (DHEA) has been shown to inhibit 11β-HSD1 in murine adipocytes; however, rodent adrenals do not produce DHEA physiologically. Here, we aimed to determine the effects and underlying mechanisms of the...

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Publication status:
Published

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Publisher copy:
10.1152/ajpendo.00314.2012

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Journal:
American journal of physiology. Endocrinology and metabolism
Volume:
305
Issue:
9
Pages:
E1134-E1144
Publication date:
2013-11-05
DOI:
EISSN:
1522-1555
ISSN:
0193-1849
URN:
uuid:c574685a-2c56-4999-80e0-70ce134bc9d8
Source identifiers:
482056
Local pid:
pubs:482056

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