Journal article
Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake.
- Abstract:
-
Glucocorticoids increase adipocyte proliferation and differentiation, a process underpinned by the local reactivation of inactive cortisone to active cortisol within adipocytes catalyzed by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The adrenal sex steroid precursor dehydroepiandrosterone (DHEA) has been shown to inhibit 11β-HSD1 in murine adipocytes; however, rodent adrenals do not produce DHEA physiologically. Here, we aimed to determine the effects and underlying mechanisms of the...
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- Publication status:
- Published
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- Publisher copy:
- 10.1152/ajpendo.00314.2012
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Bibliographic Details
- Journal:
- American journal of physiology. Endocrinology and metabolism
- Volume:
- 305
- Issue:
- 9
- Pages:
- E1134-E1144
- Publication date:
- 2013-11-01
- DOI:
- EISSN:
-
1522-1555
- ISSN:
-
0193-1849
- Source identifiers:
-
482056
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:482056
- UUID:
-
uuid:c574685a-2c56-4999-80e0-70ce134bc9d8
- Local pid:
- pubs:482056
- Deposit date:
- 2014-08-29
Terms of use
- Copyright date:
- 2013
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