Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2.

Journal article

The thermodynamic stability of nine dodecamers (four DNA and five RNA) of the same base composition has been compared by UV-melting. TheDeltaG of stabilisation were in the order: r(GACUGAUCAGUC)2>r(CGCAAATTTGCG)2 approximately r(CGCAUAUAUGCG)2>d(CGCAAATTTGCG)2 approximately r(CGCAAAUUUGCG)2>d(CGCATATATGCG)2 approximately d(GACTGATCAGTC)2>r(CGCUUUAAAGCG)2 approximately d(CGCTTTAAAGCG)2. Compared with the mixed sequences, both r(AAAUUU) and r(UUUAAA) are greatly destablising in RNA,...

Expand abstract

Authors: Conte, MR; Conn, G; Brown, T; Lane, A

• Publication status: Published
• Journal: Nucleic acids research
• Volume: 25
• Issue: 13
• Pages: 2627-2634
• Publication date: 1997-07-01
• DOI: 10.1093/nar/25.13.2627
• EISSN: 1362-4962
• ISSN: 0305-1048
• Language: English
• Keywords: DNA; Models, Molecular; Crystallography, X-Ray; RNA; Magnetic Resonance Spectroscopy; Base Sequence; Nucleic Acid Conformation; Thermodynamics; Molecular Structure; Base Composition; Drug Stability; Solutions; Ultraviolet Rays