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Tracking the dynamic interplay between bacterial and host factors during pathogen-induced vacuole rupture in real time.

Abstract:

Escape into the host cell cytosol following invasion of mammalian cells is a common strategy used by invasive pathogens. This requires membrane rupture of the vesicular or vacuolar compartment formed around the bacteria after uptake into the host cell. The mechanism of pathogen-induced disassembly of the vacuolar membrane is poorly understood. We established a novel, robust and sensitive fluorescence microscopy method that tracks the precise time point of vacuole rupture upon uptake of Gram-n...

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Authors


Danckaert, A More by this author
Paz-Haftel, I More by this author
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Journal:
Cellular microbiology
Volume:
12
Issue:
4
Pages:
545-556
Publication date:
2010-04-05
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
URN:
uuid:c55ee1c3-61d7-476b-b7d8-ea340635cd8b
Source identifiers:
249473
Local pid:
pubs:249473

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