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Journal article

The selectivity and inhibition of AlkB.

Abstract:

AlkB is one of four proteins involved in the adaptive response to DNA alkylation damage in Escherichia coli and is highly conserved from bacteria to humans. Recent analyses have verified the prediction that AlkB is a member of the Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase family of enzymes. AlkB mediates repair of methylated DNA by direct demethylation of 1-methyladenine and 3-methylcytosine lesions. Other members of the Fe(II) and 2OG-dependent oxygenase family, including those inv...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m211058200

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
278
Issue:
12
Pages:
10157-10161
Publication date:
2003-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:c5547f3a-d41c-4bf8-aa4d-379346229c07
Source identifiers:
32291
Local pid:
pubs:32291

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