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Journal article

Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis.

Abstract:

Most human aneuploidies originate maternally, due in part to the presence of highly stringent checkpoints during male meiosis. Indeed, male sterility is common among aneuploid mice used to study chromosomal abnormalities, and male germline transmission of exogenous DNA has been rarely reported. Here we show that, despite aberrant testis architecture, males of the aneuploid Tc1 mouse strain produce viable sperm and transmit human chromosome 21 to create aneuploid offspring. In these offspring,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/eLife.20235

Authors


Aitken, SJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Grant:
106563/Z/14/A; 098024/Z/11/Z
European Molecular Biology Laboratory More from this funder
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
2016; 5
Issue:
e20235
Publication date:
2016-11-18
Acceptance date:
2016-11-14
DOI:
EISSN:
2050-084X
Pubs id:
pubs:663171
URN:
uri:c5315fab-e75e-4072-bbbc-f57c18689d15
UUID:
uuid:c5315fab-e75e-4072-bbbc-f57c18689d15
Local pid:
pubs:663171

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