Adiponectin signalling in bone homeostasis, with age and in disease

Journal article

Abstract Background Smoking and nicotine impose detrimental health effects including adipose tissue dysfunction. Despite extensive physiological evidence, the cellular mechanisms remain poorly understood, with few studies examining the effects of cigarette smoke extract (CSE) or nicotine on adipocyte differentiation. Methods Primary human bone marrow-derived mesenchymal stromal cells (MSCs) were exposed to CSE or nicotine (50–500 ng/ml) during adipogenic differentiation. Cell viability and ...

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Authors: Lewis, JW; Edwards, JR; Naylor, AJ; McGettrick, HM

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer Nature [academic journals on nature.com]
• Journal: Bone Research
• Volume: 9
• Issue: 1
• Pages: 1-1
• Article number: 1
• Publication date: 2021-01-07
• DOI: 10.1038/s41413-020-00122-0
• EISSN: 2095-6231
• ISSN: 2095-4700
• Language: English
• Keywords: Endocrinology; In vitro; Medicine; Metabolic bone disease; Insulin resistance; Adiponectin; Internal medicine; Osteoblast; Adiponectin receptor 1; Biology; Osteoporosis; Insulin; Adipokine; Bone remodeling; Homeostasis; Glucose homeostasis