Psychomotor-activating effects mediated by dopamine D(2) and D(3) receptors in the nucleus accumbens.

Journal article

The contribution made by specific dopamine receptor subtypes to the induction of motor behaviors has not been firmly established. Here, we first characterized the behavioral effects induced by a D(2)-class receptor agonist, bromocriptine, following injections into the nucleus accumbens (Acb). Bromocriptine showed an atypical D(2)-class receptor agonist profile, having no observable effect on a range of motor behaviors. However, when coadministered with the D(1)-class receptor agonist SKF 3839...

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Authors: Canales, J; Iversen, S

• Publication status: Published
• Journal: Pharmacology, biochemistry, and behavior
• Volume: 67
• Issue: 1
• Pages: 161-168
• Publication date: 2000-09-01
• DOI: 10.1016/s0091-3057(00)00311-7
• EISSN: 1873-5177
• ISSN: 0091-3057
• Language: English
• Keywords: Rats, Wistar; Grooming; Rats; Pyrrolidines; Indoles; Receptors, Dopamine D1; Receptors, Dopamine D2; Motor Activity; Behavior, Animal; Receptors, Dopamine D3; Oxazines; Naphthalenes; Bromocriptine; Nucleus Accumbens; Benzopyrans; Piperidines; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals