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Journal article

Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats.

Abstract:

BACKGROUND AND PURPOSE: Studies show that blocking the activation of caspases by the caspase inhibitors z-VAD.FMK and z-DEVD.FMK can reduce ischemic neuronal injury after cerebral ischemia. Because the severity of ischemia was mild in some studies, we tested the efficacy of these caspase inhibitors on moderately severe but transient forebrain and focal ischemic insults in the rat. METHODS: Various regimens of z-VAD, z-DEVD, and control DMSO were given to rats subjected to either 4-vessel occl...

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Publication status:
Published

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Publisher copy:
10.1161/01.str.31.1.176

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Stroke and Geratology
Role:
Author
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Journal:
Stroke; a journal of cerebral circulation
Volume:
31
Issue:
1
Pages:
176-182
Publication date:
2000-01-01
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
Source identifiers:
79154
Language:
English
Keywords:
Pubs id:
pubs:79154
UUID:
uuid:c506fdef-431a-4f9c-b42a-a8d25c47820d
Local pid:
pubs:79154
Deposit date:
2012-12-19

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