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Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A.

Abstract:

Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation at the central spindle. KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1. In the presence of phosphorylated KIF4A, microtubules grew more slowly and...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.201301094

Authors


Nunes Bastos, R More by this author
Gandhi, SR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
The Journal of cell biology
Volume:
202
Issue:
4
Pages:
605-621
Publication date:
2013-08-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:c4fa5a9c-bd03-4c4f-8bdf-06b67808e265
Source identifiers:
418316
Local pid:
pubs:418316

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