Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway.

Journal article

OBJECTIVES: To determine if peripheral blood monocytes from patients with ankylosing spondylitis (AS) differed in protein expression compared to rheumatoid arthritis (RA) and healthy controls (HC). METHODS: Monocyte protein expression was characterised by 2D gel electrophoresis and by label-free quantitative expression profiling, using nano-ultra performance liquid chromatography coupled to electrospray ionisation mass spectrometry (ESI-MS(E), where (E) refers to low/high collision energy swi...

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Authors: Wright, C; Edelmann, M; diGleria, K; Kollnberger, S; Kramer, H

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 68
• Issue: 10
• Pages: 1626-1632
• Publication date: 2009-10-01
• DOI: 10.1136/ard.2008.097204
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Monocytes; Humans; Up-Regulation; Middle Aged; Female; Arthritis, Rheumatoid; Inflammation Mediators; Male; Aged; Blood Proteins; Spondylitis, Ankylosing; HLA-B27 Antigen; Proteasome Endopeptidase Complex; Proteomics; Electrophoresis, Gel, Two-Dimensional; Muscle Proteins; Adult; Ubiquitin