Journal article icon

Journal article

The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism.

Abstract:

Hyperpolarized (13)C-labeled substrates directly provide a source of magnetic resonance (MR) signal to observe the substrates' real-time uptake and enzymatic conversion. The aim of this study was to optimize the concentration of hyperpolarized [1-(13)C]pyruvate infused as a metabolic tracer, by observing the mitochondrial conversion of pyruvate to H(13)CO(3)(-) in heart tissue. Hyperpolarized pyruvate was infused into rats at concentrations between 20 mM and 80 mM and the relationships betwee...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/mrm.21934

Authors


Schroeder, MA More by this author
Atherton, HJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Expand authors...
Journal:
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume:
61
Issue:
5
Pages:
1007-1014
Publication date:
2009-05-05
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
URN:
uuid:c4e34c46-7d3a-4577-b26a-1c4a3bc28b66
Source identifiers:
106479
Local pid:
pubs:106479

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP