- Abstract:
-
Hyperpolarized (13)C-labeled substrates directly provide a source of magnetic resonance (MR) signal to observe the substrates' real-time uptake and enzymatic conversion. The aim of this study was to optimize the concentration of hyperpolarized [1-(13)C]pyruvate infused as a metabolic tracer, by observing the mitochondrial conversion of pyruvate to H(13)CO(3)(-) in heart tissue. Hyperpolarized pyruvate was infused into rats at concentrations between 20 mM and 80 mM and the relationships betwee...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/mrm.21934
-
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- Journal:
- Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
- Volume:
- 61
- Issue:
- 5
- Pages:
- 1007-1014
- Publication date:
- 2009-05-05
- DOI:
- EISSN:
-
1522-2594
- ISSN:
-
0740-3194
- URN:
-
uuid:c4e34c46-7d3a-4577-b26a-1c4a3bc28b66
- Source identifiers:
-
106479
- Local pid:
- pubs:106479
- Copyright date:
- 2009
Journal article
The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism.
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