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Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.

Abstract:

Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to explain the inability of NK cells to kill the semiallogeneic fetal cells. However, the actual functions of decidual NK (dNK) cells during pregnancy are mostly unknown. Here we show that dNK cells, but not peripheral blood-derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the ...

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Publisher copy:
10.1038/nm1452

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Journal:
Nature medicine
Volume:
12
Issue:
9
Pages:
1065-1074
Publication date:
2006-09-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:c4dcfebd-be33-49a3-a865-8628451f63cc
Source identifiers:
482822
Local pid:
pubs:482822

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