Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits.

Journal article

Our previous studies showed that decreased nitric oxide (NO) production enhanced carotid body (CB) chemoreceptor activity in chronic heart failure (CHF) rabbits. In the present study, we investigated the effects of neuronal NO synthase (nNOS) gene transfer on CB chemoreceptor activity in CHF rabbits. The nNOS protein expression and NO production were suppressed in CBs (P<0.05) of CHF rabbits, but were increased 3 days after application of an adenovirus expressing nNOS (Ad.nNOS) to the CB. ...

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Authors: Li, Y; Li, Y; Liu, D; Cornish, K; Patel, K

• Publication status: Published
• Journal: Circulation research
• Volume: 97
• Issue: 3
• Pages: 260-267
• Publication date: 2005-08-01
• DOI: 10.1161/01.res.0000175722.21555.55
• EISSN: 1524-4571
• ISSN: 0009-7330
• Language: English
• Keywords: Animals; Carotid Body; Chemoreceptor Cells; Heart Failure; Male; Gene Transfer, Horizontal; Nerve Tissue Proteins; Nitric Oxide Synthase Type I; Adenoviridae; Kidney; Rabbits; Sympathetic Nervous System; Nitric Oxide; Nitric Oxide Synthase