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H2-driven Biocatalytic Hydrogenation in Continuous Flow using Enzyme-Modified Carbon Nanotube Columns

Abstract:
We describe implementation of a system of immobilised enzymes for H2-driven NADH recycling coupled to a selective biotransformation to enable H2-driven biocatalysis in flow. This approach represents a platform that can be optimised for a wide range of hydrogenation steps and is shown here for enantioselective ketone reduction and reductive amination.
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1039/C7CC04465H

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Materials
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Materials
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
More from this funder
Grant:
EP/J500495/1
EP/L505031/1
IB Catalyst award EP/N013514/1
INSPIRE award EP/J015202/1
More from this funder
Grant:
CONTACTFP7-PEOPLE-ITN-2008-238363, BCN-Tubes-FP6-2004-NMP-TI- 4-033350
More from this funder
Grant:
EnergyBioCatalysis-ERC-2010-StG-258600, DEDIGROWTH-ERC-2009-StG- 240500, DEVICE-ERC-2011-PoC-309786, CONDUCT-ERCPoC2015-680559
Royal Society More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communications Journal website
Volume:
53
Issue:
71
Pages:
9839-9841
Publication date:
2017-08-04
Acceptance date:
2017-08-02
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Keywords:
Pubs id:
pubs:710212
UUID:
uuid:c4a2b312-38f5-4d30-9828-cb6793e2f255
Local pid:
pubs:710212
Source identifiers:
710212
Deposit date:
2017-08-02

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