Conference item
Thoracoscopic evaluation of the effect of tumour burden on the outcome of pleurodesis in malignant pleural effusion
- Abstract:
- Background: It has been postulated that when the intrapleural tumour burden is high, the resultant obliteration of normal mesothelial cell surface of the pleura results in reduction in pleurodesis success rate. Aims: to assess the hypothesis that tumour burden is associated with higher pleurodesis failure, and that tumour type can affect pleurodesis outcomes Methods: Review of recorded video footage of local anaesthetic thoracoscopy (LAT) procedures of 45 patients with proven MPE was conducted by 2 independent assessors blinded to the patient medical records. Abnormalities were assessed according to the presence or absence of; nodules, lymphangitis, inflammation, and adhesions on each of the parietal, visceral and diaphragmatic surfaces. A macroscopic score was developed by adding the number of abnormalities in each pleural surface to produce a total score for tumour burden which was correlated with tumour type and pleurodesis outcome Results: In both mesothelioma (n=21) and non-mesothelioma (n=24), there were no significant differences between the tumour burden score and the outcome of pleurodesis (p=0.188 and 0.173 respectively). The rate of pleurodesis success was higher in the non-mesothelioma group (n=16; 66.7%) compared to the mesothelioma group (n= 9; 42.9%) with no significant difference between both groups (p=0.11) Conclusion: We found no relationship between tumor burden and pleurodesis outcome. Further prospective evaluation in a larger cohort is underway. Consistent with the reported literature, we found that mesothelioma has a high failure rate of pleurodesis compared to non-mesothelioma patients
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 61.9KB, Terms of use)
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- Publisher copy:
- 10.1183/13993003.congress-2021.PA3792
Authors
- Publisher:
- European Respiratory Society
- Journal:
- European Respiratory Journal More from this journal
- Volume:
- 58
- Article number:
- PA3792
- Publication date:
- 2021-11-25
- Acceptance date:
- 2021-09-05
- Event title:
- ERS International Congress 2021
- Event start date:
- 2021-09-05
- Event end date:
- 2021-09-08
- DOI:
- EISSN:
-
1399-3003
- ISSN:
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0903-1936
Terms of use
- Copyright holder:
- Ellayeh et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright © the authors 2021
- Notes:
-
This is the accepted manuscript version of the article. The final version is available from European Respiratory Society at https://doi.org/10.1183/13993003.congress-2021.PA3792
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