Journal article
Association between physical activity and cancer risk among Chinese adults: a 10-year prospective study
- Abstract:
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Background: In China, the quantity of physical activity differs from that in Western countries. Substantial uncertainty remains about the relevance of physical activity for cancer subtypes among Chinese adults.
Objective: This study aimed to investigate the association between total daily physical activity and the incidence of common types of cancer.
Methods: A total of 53,269 participants aged 30–79 years were derived from the Wuzhong subcohort of the China Kadoorie Biobank study during 2004–2008. We included 52,938 cancer-free participants in the final analysis. Incident cancers were identified through linkage with the health insurance system and death registries. Cox proportional hazard models were introduced to assess the associations of total daily physical activity with the incidence of 6 common types of cancer.
Results: During a follow-up of 10.1 years, 3,674 cases of cancer were identified, including 794 (21.6%) from stomach cancer, 722 (19.7%) from lung cancer, 458 (12.5%) from colorectal cancer, 338 (9.2%) from liver cancer, 250 (6.8%) from breast cancer, and 231 (6.3%) from oesophageal cancer. Compared to the participants in the lowest quartile of physical activity levels, those in the highest quartile had an 11% lower risk for total cancer incidence (hazard ratio [HR]: 0.89, 95% confidence interval [CI]: 0.81–0.99), 25% lower risk for lung cancer incidence (HR: 0.75, 95% CI: 0.60–0.94), and 26% lower risk for colorectal cancer incidence (HR: 0.74, 95% CI: 0.55–1.00). There were significant interactions of physical activity with sex and smoking on total cancer (both P for interaction < 0.005), showing a lower risk for females and never smokers (HR: 0.92, 95% CI: 0.87–0.98 and HR: 0.93, 95% CI: 0.87–0.98, respectively).
Conclusions: Higher physical activity levels are associated with a reduced risk of total, lung, and colorectal cancer.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 792.4KB, Terms of use)
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- Publisher copy:
- 10.1186/s12966-022-01390-1
Authors
- Grant:
- 212946/Z/18/Z
- 104085/Z/14/Z
- 088158/Z/09/Z
- 088158/Z/09/Z
- Publisher:
- BioMed Central
- Journal:
- International Journal of Behavioral Nutrition and Physical Activity More from this journal
- Volume:
- 19
- Issue:
- 1
- Article number:
- 150
- Place of publication:
- England
- Publication date:
- 2022-12-12
- Acceptance date:
- 2022-11-25
- DOI:
- EISSN:
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1479-5868
- ISSN:
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1479-5868
- Pmid:
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36510257
- Language:
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English
- Keywords:
- Pubs id:
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1315154
- Local pid:
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pubs:1315154
- Deposit date:
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2023-08-25
Terms of use
- Copyright holder:
- Su et al
- Copyright date:
- 2022
- Rights statement:
- © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Licence:
- CC Attribution (CC BY)
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