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How do antidepressants work? New perspectives for refining treatment approaches of the future

Abstract:

Most currently available antidepressants target monoamine neurotransmitter function. However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse the many different symptoms of depression. Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity. I...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/S2215-0366(17)30015-9

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More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Publisher:
Elsevier: Lancet Publisher's website
Journal:
Lancet Psychiatry Journal website
Volume:
4
Issue:
5
Pages:
409-418
Publication date:
2017-01-31
Acceptance date:
2016-11-23
DOI:
EISSN:
2215-0374
ISSN:
2215-0366
Pubs id:
pubs:675632
URN:
uri:c48064ac-d9cf-4d52-a4b6-f68e56175e4d
UUID:
uuid:c48064ac-d9cf-4d52-a4b6-f68e56175e4d
Local pid:
pubs:675632
Paper number:
5

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