Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder.

Journal article

BACKGROUND: Associations between a functional polymorphism in the serotonin transporter gene and amygdala activation have been found in healthy, depressed, and anxious adults. This study explored these gene-brain associations in adolescents by examining predictive effects of serotonin transporter gene variants (S and L(G) allele carriers vs. L(A) allele homozygotes) and their interaction with diagnosis (healthy vs. patients) on amygdala responses to emotional faces. METHODS: Functional magne...

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Authors: Lau, J; Goldman, D; Buzas, B; Fromm, S; Guyer, A

• Publication status: Published
• Journal: Biological psychiatry
• Volume: 65
• Issue: 4
• Pages: 349-355
• Publication date: 2009-02-01
• DOI: 10.1016/j.biopsych.2008.08.037
• EISSN: 1873-2402
• ISSN: 0006-3223
• Language: English
• Keywords: Social Perception; Genotype; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Facial Expression; Reaction Time; Anxiety; Humans; Female; Adolescent; Emotions; Depressive Disorder, Major; Serotonin Plasma Membrane Transport Proteins; Male; Psychiatric Status Rating Scales; Fear; Amygdala; DNA