Journal article
Possibly no baseline severity effect for antidepressants versus placebo but for antipsychotics. Why?
- Abstract:
- Ten years ago, a meta-regression analysis (Kirsch et al., 2008) of 35 clinical trials submitted to the FDA found that the efficacy of antidepressants compared to placebo increases with baseline severity, and that a clinically significant effect defined as an effect size of at least 0.50 can only be expected in patients with a Hamilton Depression Rating Score of approximately 28. This was interpreted by Kirsch et al. to mean that antidepressants are efficacious for depression only for patients who are severely ill at baseline. This paper had a major impact on treatment guidelines and fueled a heated discussion about the usefulness of these agents (Cipriani and Geddes, 2014).
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 424.5KB, Terms of use)
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- Publisher copy:
- 10.1007/s00406-018-0940-0
Authors
- Publisher:
- Springer
- Journal:
- European Archives of Psychiatry and Clinical Neuroscience More from this journal
- Volume:
- 268
- Issue:
- 7
- Pages:
- 621-623
- Publication date:
- 2018-09-03
- Acceptance date:
- 2018-08-02
- DOI:
- EISSN:
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1433-8491
- ISSN:
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0940-1334
- Pmid:
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30178421
- Language:
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English
- Keywords:
- Pubs id:
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pubs:915438
- UUID:
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uuid:c4457bfd-980b-4920-95e0-0399122ea96b
- Local pid:
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pubs:915438
- Source identifiers:
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915438
- Deposit date:
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2018-11-12
Terms of use
- Copyright holder:
- Springer-Verlag GmbH
- Copyright date:
- 2018
- Notes:
- © Springer-Verlag GmbH Germany, part of Springer Nature 2018. This is the accepted manuscript version of the article. The final version is available online from Springer at: 10.1007/s00406-018-0940-0
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