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WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.

Abstract:

Histone H3 lysine 4 (K4) methylation has been linked to the transcriptional activation in a variety of eukaryotic species. Here we show that a common component of MLL1, MLL2, and hSet1 H3 K4 methyltransferase complexes, the WD40-repeat protein WDR5, directly associates with histone H3 di- and trimethylated at K4 and with H3-K4-dimethylated nucleosomes. WDR5 is required for binding of the methyltransferase complex to the K4-dimethylated H3 tail as well as for global H3 K4 trimethylation and HO...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2005.03.036

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Journal:
Cell
Volume:
121
Issue:
6
Pages:
859-872
Publication date:
2005-06-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:c441e40a-d744-4b5b-bf2e-608d24693bc3
Source identifiers:
331902
Local pid:
pubs:331902

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