Journal article icon

Journal article

T-cell depletion with Campath-1H "in the bag" for matched related allogeneic peripheral blood stem cell transplantation is associated with reduced graft-versus-host disease, rapid immune constitution and improved survival.

Abstract:

We studied the outcome of 24 peripheral blood stem cell (PBSC) graft recipients, who were T-cell depleted (TCD) with either 20 mg (n = 14) or 10 mg (n = 10) Campath-1H in vitro, in comparison with a retrospective cohort of 23 unmanipulated (UM) PBSC recipients. While the neutrophil engraftment was similar, the platelet engraftment occurred earlier in the TCD group (d 11 vs 14). The incidence of acute and chronic graft-versus-host-disease (GVHD) was 8.7% and 4.4% in the TCD group, respectively...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
British journal of haematology
Volume:
121
Issue:
1
Pages:
109-118
Publication date:
2003-04-01
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
Source identifiers:
4018

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP