Retinol and retinol-binding protein stabilize transthyretin via formation of retinol transport complex.

Journal article

Transthyretin (TTR) is a plasma hormone carrier protein associated with hereditary and senile forms of systemic amyloid disease, wherein slow tetramer disassembly is thought to be an obligatory step. Plasma transport of retinol is carried out exclusively by the retinol-binding protein (RBP), through complexation with transthyretin. Using mass spectrometry to examine the subunit exchange dynamics, we find that retinol stabilizes the quaternary structure of transthyretin, through its interactio...

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Authors: Hyung, S; Deroo, S; Robinson, C

• Publication status: Published
• Journal: ACS chemical biology
• Volume: 5
• Issue: 12
• Pages: 1137-1146
• Publication date: 2010-12-01
• DOI: 10.1021/cb100144v
• EISSN: 1554-8937
• ISSN: 1554-8929
• Language: English
• Keywords: Protein Structure, Quaternary; Prealbumin; Vitamin A; Protein Binding; Crystallography, X-Ray; Protein Subunits; Protein Multimerization; Retinol-Binding Proteins; Models, Molecular