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Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.

Abstract:

Monocyte-derived dendritic cells (moDC) have been widely used in cancer immunotherapy but show significant donor-to-donor variability and low capacity for the cross-presentation of tumour-associated antigens (TAA) to CD8(+) T cells, greatly limiting the success of this approach. Given recent developments in induced pluripotency and the relative ease with which induced pluripotent stem (iPS) cell lines may be generated from individuals, we have succeeded in differentiating dendritic cells (DC)...

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Publication status:
Published

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Publisher copy:
10.1038/gt.2011.177

Authors


Ichiryu, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Gene therapy
Volume:
19
Issue:
10
Pages:
1035-1040
Publication date:
2012-10-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:c3ddb787-c2a5-4f11-beca-955ef7eb5c5c
Source identifiers:
198818
Local pid:
pubs:198818

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