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Journal article

Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFβ as potential targets.

Abstract:

The mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes are extremely rare, together constituting 10% to 15% of all chondrosarcomas. Their poor prognosis and lack of efficacious treatment emphasizes the need to elucidate the pathways playing a pivotal role in these tumors. We constructed tissue microarrays containing 42 dedifferentiated, 23 clear cell, and 23 mesenchymal chondrosarcomas and performed immunohistochemistry to study the expression of growth plate-signaling mole...

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Publication status:
Published

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Authors


van Oosterwijk, JG More by this author
van Ruler, MA More by this author
van den Akker, BE More by this author
Oosting, J More by this author
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Journal:
The American journal of pathology
Volume:
182
Issue:
4
Pages:
1347-1356
Publication date:
2013-04-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:c3d8c421-8993-4153-a1bb-c7668c0424cd
Source identifiers:
394140
Local pid:
pubs:394140

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